Journal
JOURNAL OF VIROLOGY
Volume 86, Issue 4, Pages 2067-2078Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.06451-11
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Funding
- Founding Research Centers for Emerging and Reemerging Infectious Diseases
- ERATO (Japan Science and Technology Agency)
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- National Institute of Allergy and Infectious Diseases Public Health Service
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Although O-mannosylated dystroglycan is a receptor for Lassa virus, a causative agent of Lassa fever, recent findings suggest the existence of an alternative receptor(s). Here we identified four molecules as receptors for Lassa virus: Axl and Tyro3, from the TAM family, and dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and liver and lymph node sinusoidal endothelial calcium-dependent lectin (LSECtin), from the C-type lectin family. These molecules enhanced the binding of Lassa virus to cells and mediated infection independently of dystroglycan. Axl- or Tyro3-mediated infection required intracellular signaling via the tyrosine kinase activity of Axl or Tyro3, whereas DC-SIGN- or LSECtin-mediated infection and binding were dependent on a specific carbohydrate and on ions. The identification of these four molecules as Lassa virus receptors advances our understanding of Lassa virus cell entry.
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