Journal
JOURNAL OF VIROLOGY
Volume 86, Issue 5, Pages 2729-2738Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.05591-11
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Funding
- National Institutes of Health (NIH) [AI069145, HHSN27220100004OI/HHSN27200004/D04]
- John S. Dunn Foundation
- Northeast Biodefense Center-Lipkin [AI57158]
- USAID PREDICT
- U.S. Department of Defense
- [AI079231]
- [AI070411]
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The genus Alphavirus comprises a diverse group of viruses, including some that cause severe disease. Using full-length sequences of all known alphaviruses, we produced a robust and comprehensive phylogeny of the Alphavirus genus, presenting a more complete evolutionary history of these viruses compared to previous studies based on partial sequences. Our phylogeny suggests the origin of the alphaviruses occurred in the southern oceans and spread equally through the Old and New World. Since lice appear to be involved in aquatic alphavirus transmission, it is possible that we are missing a louse-borne branch of the alphaviruses. Complete genome sequencing of all members of the genus also revealed conserved residues forming the structural basis of the El and E2 protein dimers.
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