Journal
JOURNAL OF VIROLOGY
Volume 84, Issue 16, Pages 8353-8358Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00696-10
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Funding
- Thailand Tropical Diseases Research Program [02-2-DEN-03-003]
- Medical Biotechnology Network, National Center for Genetic Engineering and Biotechnology, Thailand
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During dengue virus replication, an incomplete cleavage of the envelope glycoprotein prM, generates a mixture of mature (prM-less) and prM-containing, immature extracellular particles. In this study, sequential immunoprecipitation and cryoelectron microscopy revealed a third type of extracellular particles, the partially mature particles, as the major prM-containing particles in a dengue serotype 2 virus. Changes in the proportion of viral particles in the pr-M junction mutants exhibiting altered levels of prM cleavage suggest that the partially mature particles may represent an intermediate subpopulation in the virus maturation pathway. These findings are consistent with a model suggesting the progressive mode of prM cleavage.
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