Journal
JOURNAL OF VIROLOGY
Volume 84, Issue 20, Pages 10918-10922Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01140-10
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Founding Research Centers for Emerging and Reemerging Infectious Diseases
- ERATO (Japan Science and Technology Agency)
- National Institute of Allergy and Infectious Diseases Public Health Service
- National Institute of Allergy and Infectious Diseases [HHSN266200700010C]
- Grants-in-Aid for Scientific Research [21580372] Funding Source: KAKEN
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Reassortment is an important mechanism for the evolution of influenza viruses. Here, we coinfected cultured cells with the pandemic swine-origin influenza virus (S-OIV) and a contemporary H5N1 virus and found that these two viruses have high genetic compatibility. Studies of human lung cell lines indicated that some reassortants had better growth kinetics than their parental viruses. We conclude that reassortment between these two viruses can occur and could create pandemic H5N1 viruses.
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