Journal
JOURNAL OF VIROLOGY
Volume 84, Issue 24, Pages 13036-13039Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01194-10
Keywords
-
Categories
Funding
- National Institutes of Health [CA068782, AI073303]
Ask authors/readers for more resources
The interferon (IFN)-induced protein P56 inhibits human papillomavirus (HPV) DNA replication by binding to HPV E1, which has several distinct functions in initiating viral DNA replication. Here, we determined that P56 inhibited HPV type 18 (HPV18) E1's DNA helicase activity, E2 binding, and HPV Ori sequence-specific DNA binding but not nonspecific DNA binding. We observed that deletion of a single amino acid, F399, produced an E1 mutant that could not bind P56. This E1 mutant retained its ability to support Ori DNA replication, but this activity was not inhibited by IFN, demonstrating that P56 is the principal executor of the anti-HPV action of IFN.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available