Journal
JOURNAL OF VIROLOGY
Volume 84, Issue 20, Pages 10913-10917Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00789-10
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Funding
- National Cancer Institute [CA-100634]
- Mayo Clinic
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Measles virus (MV) entry requires at least 2 viral proteins, the hemagglutinin (H) and fusion (F) proteins. We describe the rescue and characterization of a measles virus with a specific mutation in the stalk region of H-(I98A) that is able to bind normally to cells but infects at a lower rate than the wild type due to a reduction in fusion triggering. The mutant H protein binds to F more avidly than the parent H protein does, and the corresponding virus is more sensitive to inhibition by fusion-inhibitory peptide. We show that after binding of MV to its receptor, H-F dissociation is required for productive infection.
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