Journal
JOURNAL OF VIROLOGY
Volume 85, Issue 4, Pages 1893-1895Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01741-10
Keywords
-
Categories
Funding
- Program for Promotion of Basic Research Activities for Innovative Biosciences (PROBRAIN)
Ask authors/readers for more resources
Natural isolates of Tobacco mild green mosaic virus (TMGMV) fail to infect tomato because the tomato tm-1 protein binds to the replication proteins of TMGMV and prevents RNA replication. Previously, we isolated a TMGMV mutant that overcomes tm-1-mediated resistance and multiplies in tomato plants. Here, we show that the causal mutations in the replication protein gene that abolish the interaction with tm-1 reduce its ability to suppress RNA silencing in host plant Nicotiana benthamiana. The results suggest that the multifunctionality of the replication proteins is an evolutionary constraint of tobamoviruses that restricts their host ranges.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available