Journal
JOURNAL OF VIROLOGY
Volume 84, Issue 21, Pages 11555-11559Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00652-10
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Funding
- Czech Ministry of Education [1M0508, Z4 0550506]
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The mouse mammary tumor virus ( MMTV) Gag contains the unique domains pp21, p3, p8, and n. We investigated the contribution of these domains to particle assembly and found that the region spanning the p8 and n domains is critical for shape determination and assembly. Deletion of pp21 and p3 reduced the number of released particles, but deletion of the n domain resulted in frequent formation of aberrant particles, while deletion of p8 severely impaired assembly. Further investigation of p8 revealed that both the basic and the proline-rich motifs within p8 contribute to MMTV assembly.
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