Journal
JOURNAL OF VIROLOGY
Volume 84, Issue 17, Pages 8980-8985Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00858-10
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Funding
- Wellcome Trust
- MRC [MC_U105181010, G0801822] Funding Source: UKRI
- Medical Research Council [G0801822, MC_U105181010] Funding Source: researchfish
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A synthetic feline TRIM5-cyclophilin A fusion protein (feTRIMCyp) was generated and transduced into feline cells. feTRIMCyp was highly efficient at preventing infection with human (HIV) and feline (FIV) immunodeficiency virus pseudotypes, and feTRIMCyp-expressing cells resisted productive infection with either FIV-Fca or FIV-Pco. The restriction of FIV infection by feTRIMCyp was reversed by the cyclosporine (Cs) derivatives NIM811 and Debio-025 but less so by Cs itself. FeTRIMCyp and FIV infections of the cat offer a unique opportunity to evaluate TRIMCyp-based approaches to genetic therapy for HIV infection and the treatment of AIDS.
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