Journal
JOURNAL OF VIROLOGY
Volume 85, Issue 5, Pages 2458-2462Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02138-10
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Funding
- Institut Pasteur
- ANR
- CNRS
- l'Association pour la Recherche sur le Cancer (ARC)
- La Ligue contre le Cancer
- Equipe labelisee LIGUE
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We sought to examine ADAR-1 editing of measles and influenza virus genomes derived from inactivated seasonal influenza and live attenuated measles virus vaccines grown on chicken cells as the culture substrate. Using highly sensitive 3DI-PCR (R. Suspene et al., Nucleic Acids Res. 36:e72, 2008), it was possible to show that ADAR-1 could hyperdeaminate adenosine residues in both measles virus and influenza virus A genomes. Detailed analysis of the dinucleotide editing context showed preferences for 5'ArA and 5'UrA, which is typical of editing in mammalian cells. The hyperedited mutant frequency, including genomes and antigenomes, was a log greater for influenza virus compared to measles virus, suggesting a greater sensitivity to restriction by ADAR-1.
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