Journal
JOURNAL OF VIROLOGY
Volume 84, Issue 22, Pages 12082-12086Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01466-10
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Funding
- National Institute of Allergy and Infectious Diseases, National Institutes of Health [5U01-AI1027661-19]
- Minnesota Medical Foundation
- International Center for Antiviral Research and Epidemiology
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Increased levels of activated T cells are a hallmark of the chronic stage of human immunodeficiency virus (HIV) infection and are highly correlated with HIV disease progression. We evaluated chloroquine (CQ) as a potential therapy to reduce immune activation during HIV infection. We found that the frequency of CD38(+) HLA-DR+ CD8 T cells, as well as Ki-67 expression in CD8 and CD4 T cells, was significantly reduced during CQ treatment. Our data indicate that treatment with CQ reduces systemic T-cell immune activation and, thus, that its use may be beneficial for certain groups of HIV-infected individuals.
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