Journal
JOURNAL OF VIROLOGY
Volume 83, Issue 14, Pages 7353-7356Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00546-09
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Funding
- Fred Hutchinson Cancer Research Center
- Listwin Family Foundation/Canary Foundation
- Northwest Genome Engineering Consortium [UL1 DE19582]
- Pacific Northwest Prostate Cancer Specialized Program of Research Excellence [P50 CA97186]
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The human retrovirus XMRV (xenotropic murine leukemia virus-related virus) is associated with prostate cancer, most frequently in humans with a defect in the antiviral defense protein RNase L, suggesting a role for XMRV in prostate carcinogenesis. However, XMRV has not been found in prostate carcinoma cells. Here we show that 22Rv1 prostate carcinoma cells produce high-titer virus that is nearly identical in properties and sequence to XMRV isolated by others and consist primarily of a single clone of cells with at least 10 integrated copies of XMRV, warranting further study of a possible role for XMRV integration in carcinogenesis.
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