Journal
JOURNAL OF VIROLOGY
Volume 83, Issue 21, Pages 11407-11411Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01211-09
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Funding
- Swedish Research Council
- Swedish International Development Agency
- Swedish Foundation for Strategic Research
- Swedish Physicians Against AIDS Research Foundation
- Swedish National Board of Health and Welfare
- Roche A/S Denmark
- Karolinska Institutet
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Chronic immune activation is a driver of human immunodeficiency virus type 1 (HIV-1) disease progression. Here, we describe that subjects with chronic hepatitis C virus (HCV)/HIV-1 coinfection display sharply elevated immune activation as determined by CD38 expression in T cells. This occurs, despite effective antiretroviral therapy, in both CD8 and CD4 T cells and is more pronounced than in the appropriate monoinfected control groups. Interestingly, the suppression of HCV by pegylated alpha interferon and ribavirin treatment reduces activation. High HCV loads and elevated levels of chronic immune activation may contribute to the high rates of viral disease progression observed in HCV/HIV-1-coinfected patients.
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