Journal
JOURNAL OF VIROLOGY
Volume 83, Issue 20, Pages 10515-10526Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00731-09
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Funding
- National Institute of Allergy and Infectious Disease [R01AI57988]
- National Institutes of Health [P50 CA098252, CA118790]
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Papillomavirus capsids are composed of 72 pentamers reinforced through inter- and intrapentameric disulfide bonds. Recent research suggests that virus-like particles and pseudovirions (PsV) can undergo a redox-dependent conformational change involving disulfide interactions. We present here evidence that native virions exploit a tissue-spanning redox gradient that facilitates assembly events in the context of the complete papillomavirus life cycle. DNA encapsidation and infectivity titers are redox dependent in that they can be temporally modulated via treatment of organotypic cultures with oxidized glutathione. These data provide evidence that papillomavirus assembly and maturation is redox-dependent, utilizing multiple steps within both suprabasal and cornified layers.
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