Journal
JOURNAL OF VIROLOGY
Volume 84, Issue 2, Pages 1189-1192Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01712-09
Keywords
-
Categories
Funding
- National Institute of Allergy and Infectious Diseases [AI067968]
- National Institute of Allergy and Infectious Diseases
- National Cancer Institute [T32-CA009111]
Ask authors/readers for more resources
Deep sequencing of small RNAs isolated from human sacral ganglia latently infected with herpes simplex virus 2 (HSV-2) was used to identify HSV-2 microRNAs (miRNAs) expressed during latent infection. This effort resulted in the identification of five distinct HSV-2 miRNA species, two of which, miR-H3/miR-I and miR-H4/miR-II, have been previously reported. Three novel HSV-2 miRNAs were also identified, and two of these, miR-H7 and miR-H9, are derived from the latency-associated transcript (LAT) and are located antisense to the viral transcript encoding transactivator ICP0. A third novel HSV-2 miRNA, miR-H10, is encoded within the unique long (U-L) region of the genome, 3' to the U(L)15 open reading frame, and is presumably excised from a novel, latent HSV-2 transcript distinct from LAT.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available