Journal
JOURNAL OF VIROLOGY
Volume 84, Issue 2, Pages 1183-1188Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01675-09
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Funding
- Bundesministerium fur Bildung und Forschung
- Helmholtz-Zentrum fur Infektionsforschung [IG-SCID-TwinPro02]
- Bundesministerium fur Bildung und Forschung [IND 06/20]
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HIV-1 infection is characterized by loss of CD56(dim) CD16(+) NK cells and increased terminal differentiation on various lymphocyte subsets. We identified a decrease of CD57(+) and CD57(dim) cells but not of CD57(bright) cells on CD56dim CD16(+) NK cells in chronic HIV infection. Increasing CD57 expression was strongly associated with increasing frequencies of killer immunoglobulin-like receptors (KIRs) and granzyme B-expressing cells but decreasing percentages of cells expressing CD27(+), HLA-DR+, Ki-67(+), and CD107a. Our data indicate that HIV leads to a decline of less-differentiated cells and suggest that CD57 is a useful marker for terminal differentiation on NK cells.
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