Journal
JOURNAL OF VIROLOGY
Volume 83, Issue 21, Pages 11385-11390Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01363-09
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Funding
- NIH [PO1 AI060699, R37 AI022931, R01AI058129]
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We evaluated the efficacy of rhesus theta-defensin 1 (RTD-1), a novel cyclic antimicrobial peptide, as a prophylactic antiviral in a mouse model of severe acute respiratory syndrome (SARS) coronavirus (CoV) lung disease. BALB/c mice exposed to a mouse-adapted strain of SARS-CoV demonstrated 100% survival and modest reductions in lung pathology without reductions in virus titer when treated with two intranasal doses of RTD-1, while mortality in untreated mice was similar to 75%. RTD-1-treated, SARS-CoV-infected mice displayed altered lung tissue cytokine responses 2 and 4 days postinfection compared to those of untreated animals, suggesting that one possible mechanism of action for RTD-1 is immunomodulatory.
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