Journal
JOURNAL OF VIROLOGY
Volume 83, Issue 13, Pages 6952-6956Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00480-09
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Funding
- NIH
- National Institute of Child Health and Human Development
- Trans NIH Biodefense Program
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The viral protein VP35 of ebolavirus (EBOV) is implicated to have diverse roles in the viral life cycle. We employed a yeast two-hybrid screen to search for VP35 binding partners and identified the cytoplasmic dynein light chain (DLC8) as a protein that interacts with VP35. Mapping analysis unraveled a consensus motif, SQTQT, within VP35 through which VP35 binds to DLC8. The disruption of DLC8 binding does not affect the ability of VP35 to inhibit type I IFN production. Given that VP35 from various EBOV species interacts with DLC8, this interaction may have a role in regulating the EBOV life cycle.
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