Journal
JOURNAL OF VIROLOGY
Volume 83, Issue 16, Pages 8270-8275Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00670-09
Keywords
-
Categories
Funding
- Public Health Service [AI049765]
- Wellcome Trust
- BBSRC [BB/D008425/1] Funding Source: UKRI
- MRC [G9721629, G0801172, G0300387] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D008425/1] Funding Source: researchfish
- Medical Research Council [G0801172, G9721629, G0300387] Funding Source: researchfish
Ask authors/readers for more resources
TRIM5 alpha mediates a potent retroviral restriction phenotype in diverse mammalian species. Here, we identify a TRIM5 transcript in cat cells with a truncated B30.2 capsid binding domain and ablated restrictive function which, remarkably, is conserved across the Feliformia. Cat TRIM5 displayed no restriction activity, but ectopic expression conferred a dominant negative effect against human TRIM5 alpha. Our findings explain the absence of retroviral restriction in cat cells and suggest that disruption of the TRIM5 locus has arisen independently at least twice in the Carnivora, with implications concerning the evolution of the host and pathogen in this taxon.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available