Journal
JOURNAL OF VIROLOGY
Volume 83, Issue 11, Pages 5951-5955Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00171-09
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Funding
- Canadian Institutes of Health Research (CIHR)
- Natural Sciences and Engineering Research Council (NSERC) of Canada
- Nova Scotia Health Research Foundation (NSHRF)
- Cancer Research Training Program (CRTP)
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As nonenveloped viruses, the aquareoviruses and orthoreoviruses are unusual in their ability to induce cell-cell fusion and syncytium formation. While an extraordinary family of fusion-associated small transmembrane (FAST) proteins is responsible for orthoreovirus syncytiogenesis, the basis for aquareovirus-induced syncytiogenesis is unknown. We now report that the S7 genome segment of an Atlantic salmon reovirus is polycistronic and uses a noncanonical CUG translation start codon to produce a 22-kDa integral membrane protein responsible for syncytiogenesis. The aquareovirus p22 protein represents a fourth distinct member of the FAST family with a unique repertoire and arrangement of structural motifs.
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