Journal
JOURNAL OF VIROLOGY
Volume 83, Issue 23, Pages 12622-12625Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01201-09
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Funding
- Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Science Research on Priority Areas
- Japan Science and Technology Agency
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Borna disease virus (BDV) is characterized by highly neurotropic infection. BDV enters its target cells using virus surface glycoprotein (G), but the cellular molecules mediating this process remain to be elucidated. We demonstrate here that the N-terminal product of G, GP1, interacts with the 78-kDa chaperone protein BiP. BiP was found at the surface of BDV-permissive cells, and anti-BiP antibody reduced BDV infection as well as GP1 binding to the cell surface. We also reveal that BiP localizes at the synapse of neurons. These results indicate that BiP may participate in the cell surface association of BDV.
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