Journal
JOURNAL OF VIROLOGY
Volume 82, Issue 16, Pages 8215-8223Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02575-07
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Funding
- NCI NIH HHS [CA06927, P30 CA006927] Funding Source: Medline
- NIAID NIH HHS [U01 AI061441, AI061441, R01 AI026522, AI26522] Funding Source: Medline
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The liver-specific microRNA miR-122 has been shown to be required for the replication of hepatitis C virus (HCV) in the hepatoma cell line Huh7. The aim of this study was to test if HCV replication can be modulated by exogenously expressed miR-122 in human embryonic kidney epithelial cells (HEK-293). Our results demonstrate that miR-122 enhances the colony formation efficiency of the HCV replicon and increases the steady-state level of HCV RNA in HEK-293 cells. Therefore, we conclude that although miR-122 is not absolutely required, it greatly enhances HCV replication in nonhepatic cells.
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