Journal
JOURNAL OF VIROLOGY
Volume 83, Issue 2, Pages 662-672Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01328-08
Keywords
-
Categories
Funding
- PHS [NIH-P01-AI054564]
- Center for AIDS
- University of Washington [P30 AI27757]
- James B. Pendleton Charitable Trust
- Murdock Charitable Trust
Ask authors/readers for more resources
We assessed differences in the character and specificity of autologous neutralizing antibodies (ANAbs) against individual viral variants of the quasispecies in a cohort of drug-naive subjects with long-term controlled human immunodeficiency virus type 1 (HIV-1) infection and moderate levels of broad heterologous neutralizing antibodies (HNAb). Functional plasma virus showed continuous env evolution despite a short time frame and low levels of viral replication. Neutralization-sensitive variants dominated in subjects with intermittent viral blips, while neutralization-resistant variants predominated in elite controllers. By sequence analysis of this panel of autologous variants with various sensitivities to neutralization, we identified more than 30 residues in envelope proteins (Env) associated with resistance or sensitivity to ANAbs. The appearance of new sensitive variants is consistent with a model of continuous selection and turnover. Strong ANAb responses directed against autologous Env variants are present in long-term chronically infected individuals, suggesting a role for these responses in contributing to the durable control of HIV replication.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available