Journal
JOURNAL OF VIROLOGY
Volume 82, Issue 20, Pages 10302-10307Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01255-08
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Funding
- Ministerio de Ciencia y Tecnologia [SAF2005-05633]
- Deutsche Forschungsgemeinschaft [SFB 587, A13]
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The human cytomegalovirus (HCMV) major immediate-early enhancer has been postulated to play a pivotal role in the control of latency and reactivation. However, the absence of an animal model has obstructed a direct test of this hypothesis. Here we report on the establishment of an in vivo, experimentally tractable system for quantitatively investigating physiological functions of the HCMV enhancer. Using a neonate BALB/c mouse model, we show that a chimeric murine CMV under the control of the HCMV enhancer is competent in vivo, replicating in key organs of mice with acute CMV infection and exhibiting latency/reactivation features comparable for the most part to those of the parental and revertant viruses.
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