Journal
JOURNAL OF VIROLOGY
Volume 82, Issue 9, Pages 4675-4679Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02445-07
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NCI NIH HHS [R37 CA 30488, R37 CA030488] Funding Source: Medline
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TRIM28 is a transcriptional corepressor which is required for primer binding site (PBS)-dependent restriction of murine leukemia virus (MLV) replication in embryonic stem and embryonic carcinoma (EC) cells. PBS-dependent restriction of MLV leads to transcriptional silencing of the integrated provirus and has been shown to correlate with TRIM28-mediated recruitment of HP1 to the silenced loci. Here we show, using a cell line with a point mutation in the HP1 binding domain of TRIM28, that interaction with HP1 is absolutely required for the PBS-dependent restriction of MLV in the F9 EC cell line.
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