Journal
JOURNAL OF VIROLOGY
Volume 83, Issue 6, Pages 2770-2777Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01841-08
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Funding
- French Agency for AIDS Research (ANRS)
- Institut Pasteur
- NIH [R21 AI68583, DPI OD00329]
- Public Health Services [U51RR00169]
- National Institute of Allergy and Infectious Diseases [P01 AI066314]
- James B. Pendleton Charitable Trust
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Nonpathogenic simian immunodeficiency virus SIVagm infection of African green monkeys (AGMs) is characterized by the absence of a robust antibody response against Gag p27. To determine if this is accompanied by a selective loss of T-cell responses to Gag p27, we studied CD4(+) and CD8(+) T-cell responses against Gag p27 and other SIVagm antigens in the peripheral blood and lymph nodes of acutely and chronically infected AGMs. Our data show that AGMs can mount a T-cell response against Gag p27, indicating that the absence of anti-p27 antibodies is not due to the absence of Gag p27-specific T cells.
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