Journal
JOURNAL OF VIROLOGY
Volume 83, Issue 4, Pages 2029-2033Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01349-08
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Funding
- Canadian Institutes of Health Research (CIHR)
- International Partnership on Microbicides (IPM)
- CIHR
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We propose that a nucleotide template-based mechanism facilitates the acquisition of the K65R mutation in subtype C human immunodeficiency virus type 1 (HIV-1). Different patterns of DNA synthesis were observed using DNA templates from viruses of subtype B or C origin. When subtype C reverse transcriptase (RT) was employed to synthesize DNA from subtype C DNA templates, preferential pausing was seen at the nucleotide position responsible for the AAG-to-AGG K65R mutation. This did not occur when the subtype B RT and template were used. Template factors can therefore increase the probability of K65R development in subtype C HIV-1.
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