Journal
JOURNAL OF VIROLOGY
Volume 82, Issue 17, Pages 8896-8899Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00406-08
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Funding
- National Cancer Institute [R01 CA71878]
- National Multiple Sclerosis Society
- California Institute of Regenerative Medicine (CIRM) [RS1-409, T1-00008]
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We studied the susceptibility of human embryonic stem cell-derived oligodendrocyte progenitor cells to infection with JC virus, the causative agent of progressive multifocal leukoencephalopathy (PML). A human embryonic stem cell line, H7, was used to derive an enriched population of cells expressing the oligodendrocyte progenitor cell-specific marker NG2. These cells expressed the 5HT(2a) receptor (5HT(2a)R) for JC virus and were highly susceptible to infection. Infection was reduced by treatment with anti-511T(2a)R antibodies and by the 5HT(2a)R antagonists ritanserin and ketanserin. This is the first demonstration that human embryonic stem cell-derived oligodendrocyte progenitor cells are susceptible to JC virus infection and indicates that cells poised to replenish mature oligodendrocytes in PML lesions may also be a target of viral infection.
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