Journal
JOURNAL OF VIROLOGY
Volume 82, Issue 17, Pages 8882-8886Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00920-08
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Funding
- National Multiple Sclerosis Society [FG 1431-A-1, RG3774A2-1]
- M. E. Groff Surgical Medical Research and Education Charitable Trust [F76401]
- NIH [EY015098]
- Paul and Evanina Mackall Foundation Trust
- F. M. Kirby Foundation
- NATIONAL EYE INSTITUTE [K08EY015098] Funding Source: NIH RePORTER
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Optic neuritis (ON), an inflammatory demyelinating optic nerve disease, occurs in multiple sclerosis (MS). Pathological mechanisms and potential treatments for ON have been studied via experimental autoimmune MS models. However, evidence suggests that virus-induced inflammation is a likely etiology triggering MS and ON; experimental virus-induced ON models are therefore required. We demonstrate that MHV-A59, a mouse hepatitis virus (MHV) strain that causes brain and spinal cord inflammation and demyelination, induces ON by promoting mixed inflammatory cell infiltration. In contrast, MHV-2, a nondemyelinating MHV strain, does not induce ON. Results reveal a reproducible virus-induced ON model important for the evaluation of novel therapies.
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