Journal
JOURNAL OF VIROLOGY
Volume 82, Issue 17, Pages 8942-8946Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00676-08
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Funding
- Naito Foundation
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
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Human metapneumovirus (HMPV) is a major causative agent of severe bronchiolitis and pneumonia. Its fusion (F) protein must be cleaved by host proteases to cause membrane fusion, a critical step for virus infection. By generating Vero cells constitutively expressing the transmembrane serine protease TMPRSS2 and green fluorescent protein-expressing recombinant HMPV, we show that TMPRSS2, which is expressed in the human lung epithelium, cleaves the HMPV F protein efficiently and supports HMPV multiplication. The results indicate that TMPRSS2 is a possible candidate protease involved in the development of lower respiratory tract illness in HMPV-infected patients.
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