Journal
JOURNAL OF VIROLOGY
Volume 82, Issue 8, Pages 4164-4168Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02621-07
Keywords
-
Categories
Funding
- NIAID NIH HHS [U54-AI057158, N01AI50031, AI 055749, AI-50031, R01 AI055749, U54 AI057158] Funding Source: Medline
- NIA NIH HHS [K99 AG029726, 1K99AG029726] Funding Source: Medline
Ask authors/readers for more resources
Determining how West Nile virus crosses the blood-brain barrier is critical to understanding the pathogenesis of encephalitis. Here, we show that ICAM-1(-/-) mice are more resistant than control animals to lethal West Nile encephalitis. ICAM-1(-/-) mice have a lower viral load, reduced leukocyte infiltration, and diminished neuronal damage in the brain compared to control animals. This is associated with decreased blood-brain barrier leakage after viral infection. These data suggest that ICAM-1 plays an important role in West Nile virus neuroinvasion and that targeting ICAM-1 signaling may help control viral encephalitis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available