Journal
JOURNAL OF VIROLOGY
Volume 82, Issue 19, Pages 9795-9799Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01217-08
Keywords
-
Categories
Funding
- Fundacao para a Ciencia e a Tecnologia (FCT)
- Programa Operacional Ciencia a Inovacao 2010 [POCI 2010]
- FCT
Ask authors/readers for more resources
Human immunodeficiency virus type 2 (HIV-2) infection, unlike HIV-1 infection, is normally characterized by low rates of CD4 depletion and low-to-undetectable viremia. We found that the frequency of Gag-specific CD4(+) T cells featured positive correlations with the expression of markers of CD4 activation and a negative correlation with peripheral blood mononuclear cell-associated proviral load in infection with HIV-2, in contrast with HIV-1. Moreover, HIV-2-infected individuals exhibited a greater ability to respond to HIV-1 Gag peptides (heterologous responses). Our data suggest a potential link between HIV-2-specific CD4 responses, immune activation, and viral control, which may in turn relate to the better prognosis associated with HIV-2 infection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available