Journal
JOURNAL OF VIROLOGICAL METHODS
Volume 173, Issue 2, Pages 353-356Publisher
ELSEVIER
DOI: 10.1016/j.jviromet.2011.03.009
Keywords
HIV; Diagnosis; Rapid test; Antibody; Seroconversion
Funding
- Fundacao para a Ciencia e Tecnologia (FCT) [POCI/SAU-IMI/55726/2004]
- Coordenacao Nacional para a Infeccao VIH/SIDA - Alto Comissariado da Sailde [CNIVS 28-1.7.3/2004]
- Merck Sharp Dohme Portugal
- Gilead Sciences Portugal
- Fundação para a Ciência e a Tecnologia [POCI/SAU-IMI/55726/2004] Funding Source: FCT
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The use of rapid human immunodeficiency virus (HIV) antibody tests can help reduce the number of individuals positive for HIV who are unaware of their infection. Although several studies have demonstrated that the sensitivity and specificity of rapid HIV tests are comparable to those of enzyme immunoassays, none have addressed the rapidity with which these tests can yield a result and the reliability of such results. In this study, we investigated the performance of VIKIA (R) HIV1/2 rapid tests regarding early reactive results and the stability of these results after sample addition. The results showed that using HIV-1 or HIV-2 positive samples, a positive result could be observed as early as 1 min after the addition of the sample. The ability of this test to detect early HIV-1 primary infection was also assessed using seroconversion specimens. The results demonstrate the high sensitivity of this test, and its suitability for the identification of seroconversion samples in the context of primary infection with HIV-1. (C) 2011 Elsevier B.V. All rights reserved.
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