Journal
JOURNAL OF VIROLOGICAL METHODS
Volume 165, Issue 2, Pages 211-215Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jviromet.2010.01.021
Keywords
Chimeric CMV particles; HCV; Edible vaccine
Funding
- Ministero dell'Istruzione dell'Universita e della Ricerca (MIUR), Italy [2003070899]
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The Cucumber mosaic virus (CMV) is an isodiametric plant virus with an extremely wide host range, present worldwide. CMV chimeric particles (R9-CMV), engineered to express a 27-aa synthetic peptide derived from Hepatitis C virus (HCV), were demonstrated to be stable under simulated gastric and intestinal conditions. Then the possibility of inducing a humoral immune response in rabbits fed with R9-CMV infected lettuce plants was demonstrated, suggesting that this system could function as a confirming tool of a bioreactor for the production of a stable edible vaccine against HCV. (C) 2010 Elsevier B.V. All rights reserved.
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