Journal
JOURNAL OF VETERINARY SCIENCE
Volume 11, Issue 2, Pages 165-167Publisher
KOREAN SOC VETERINARY SCIENCE
DOI: 10.4142/jvs.2010.11.2.165
Keywords
cross-reactivity; HCoV 229E; HCoV OC43; recombinant nucleocapsid protein; SARS
Categories
Funding
- Korea Food and Drug Administration
- Korea Research Foundation [KRF-005-E00077]
- BK21 Program for Veterinary Science
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Severe acute respiratory syndrome (SARS) is a life-threatening disease for which accurate diagnosis is essential. Although many tools have been developed for the diagnosis of SARS, false-positive reactions in negative sera may occur because of cross-reactivity with other coronaviruses. We have raised polyclonal and monoclonal antibodies (Abs) using a recombinant form of the SARS virus nucleocapsid protein. Cross-reactivity of these anti-SARS Abs against human coronavirus (HCoV) 229E and HCoV OC43 were determined by Western blotting. The Abs produced reacted with recombinant SARS virus nucleocapsid protein, but not with HCoV 229E or HCoV OC43.
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