Journal
JOURNAL OF VETERINARY SCIENCE
Volume 10, Issue 2, Pages 165-167Publisher
KOREAN SOC VETERINARY SCIENCE
DOI: 10.4142/jvs.2009.10.2.165
Keywords
beta-glucan; macrophages; nitric oxide; Paenibacillus polymyxa
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Funding
- Korean Government [KRF-2008-521-E00146]
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The effect of extracellular beta-(1 -> 3), (1 -> 6)-glucan, produced by Paenibacillus polymyxa JB115, on nitric oxide (NO) production in RAW264.7 macrophages was investigated. beta-glucan induced the production of NO by RAW264.7 macrophages in a concentration- and time-dependent manner. Moreover, beta-glucan stimulation increased the mRNA expression of iNOS, COX-2 and IL-6 in RAW264.7 macrophages in a concentration-dependent manner.
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