Pharmacokinetics of enrofloxacin in allogynogenetic silver crucian carp, Carassius auratus gibelio

Fang, X., Liu, X., Liu, W., Lu, C. Pharmacokinetics of enrofloxacin in allogynogenetic silver crucian carp, Carassius auratus gibelio. J. vet. Pharmacol. Therap. 35, 397-401. The pharmacokinetics of enrofloxacin (EF) was investigated after single intravenous (i.v.) and oral (p.o.) administration of 10 mg/kg body weight (b.w.) in 300 healthy allogynogenetic silver crucian carp at 2426 degrees C. The plasma concentrations of EF and its metabolite ciprofloxacin (CF) were determined by high-performance liquid chromatography. After i.v. administration, the plasma concentrationtime data were described by an open two-compartment model. The elimination half-life (T1/2 beta), area under the concentrationtime curve (AUC) and total body clearance of EF were 63.5 h, 239.6 mu g center dot h/mL and 0.04 L/h/kg, respectively. Following p.o. administration, the plasma concentrationtime data showed a double peakshaped curve, indicating the possibility of enterohepatic recirculation of EF in allogynogenetic silver crucian carp. The maximum plasma concentration (Cmax), T1/2 beta and AUC of EF were 4.5 mu g/mL, 62.7 h and 205.9 mu g center dot h/mL, respectively. Absorption of EF was very good with a bioavailability (F) of 86%, which could be correlated with the unique structure of the alimentary canal in allogynogenetic silver crucian. CF, an active metabolite of EF, was not detected in this study.