Journal
JOURNAL OF VETERINARY MEDICAL SCIENCE
Volume 74, Issue 10, Pages 1363-1366Publisher
JAPAN SOC VET SCI
DOI: 10.1292/jvms.12-0176
Keywords
arenavirus; lymphocytic choriomeningitis virus; pseudotype; receptor
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Funding
- Contract Research Fund for the Program of Founding Research Centers for Emerging and Reemerging Infectious Diseases
- ERATO (Japan Science and Technology Agency)
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- National Institute of Allergy and Infectious Diseases Public Health Service research grants
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The glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV), the prototype arenavirus, is a promising envelope protein of lentiviral pseudotype vectors for gene therapy. The distribution of dystroglycan, a known receptor for [CM V, cannot explain the narrow tropism of LCMV-GP-pseudotypes. Here, we examined whether infection of LCMV-GP-pseudotypes was affected by the expression of four cell surface molecules-Axl and Tyro3 (from the TAM family) and DC-SIGN and LSECtin (from the C-type lectin family)-that are known receptors of Lassa virus, another arenavirus. All four molecules enhanced LCMV-GP-pseudotype infection of cells. These results help explain the tropism of LCMV-GP-pseudotypes and further our understanding of LCMV infection in animals.
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