Journal
JOURNAL OF VETERINARY MEDICAL SCIENCE
Volume 74, Issue 5, Pages 677-680Publisher
JAPAN SOC VET SCI
DOI: 10.1292/jvms.11-0453
Keywords
canine; chronic lymphocytic leukemia; high-grade lymphoma; PARR; second malignancy
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Funding
- Japan Society for the Promotion of Science (JSPS) [23780322]
- Grants-in-Aid for Scientific Research [23780322, 23380186] Funding Source: KAKEN
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Second malignancies are frequent complications in human patients with chronic lymphocytic leukemia (CLL). However, the clinical details and outcome of this phenomenon were unclear in their canine counterparts. Here, we report a dog with high-grade lymphoma concurrent with T-cell CLL. A 10-year-old male golden retriever presented with lymphadenopathies. The lymph nodes contained large-sized lymphocytes, raising suspicion of high-grade lymphoma. Meanwhile, small lymphocytic lymphocytosis in the peripheral blood was consistent with CLL. Interestingly, molecular biological analyses revealed that CLL cells were of the T-cell type, whereas lymphoma cells were of the B-cell type. Chemotherapy using the L-VCA short protocol was effective for 155 days, but the dog died on day 194 after diagnosis, despite rescue therapies.
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