Journal
JOURNAL OF VETERINARY MEDICAL SCIENCE
Volume 74, Issue 11, Pages 1517-1521Publisher
JAPAN SOC VET SCI
DOI: 10.1292/jvms.12-0058
Keywords
canine; CCNU; MRI; glioma; radiation therapy
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A 9 year-old, neutered, male French Bulldog showing cluster seizures was diagnosed with a glioma in the right piriform cortex by MRI. Hypofractionated radiation therapy (RT) was performed using a linear accelerator. Although the lesion had involuted significantly at 2 months after RT, recurrence was observed at 4 months after RT. Chemotherapy was started using CCNU (60 mg/m(2) every 6-9 weeks) and was continued for one year. Follow-up MM revealed involution of the lesion and the intervals of CCNU were increased to every 9-14 weeks. Two years after the first presentation, the dog suffered status epilepticus, followed by deficits of left sided postural reaction with cognitive dysfunction. The dog died on day 910, and histopathological diagnosis confirmed anaplastic oligodenclroglioma.
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