Journal
JOURNAL OF VETERINARY MEDICAL SCIENCE
Volume 72, Issue 11, Pages 1521-1526Publisher
JAPAN SOC VET SCI
DOI: 10.1292/jvms.10-0100
Keywords
cytokine; IL-1 beta; interleukin-1; Macropus eugenii; marsupial
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Funding
- CQUniversity Faculty Research Grant
- CQUniversity's Centre for Environmental Management
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Interleukin-1 beta (IL-1,beta) plays a significant role in the onset and pathogenesis of inflammation in mammalian hosts. Although well characterized in a range of vertebrate species, little is known about this important cytokine in marsupial mammals. We report here the molecular cloning and characterization of IL-1 beta in the tammar wallaby (Macropus eugenii). M. eugenii IL-1 beta has an open-reading frame of 813 nucleotides, coding for a putative protein of 270 amino acids to the termination codon. The IL-1 family motif and potential caspase cleavage site (necessary for production of the mature protein) is also present in the sequence. Molecular characterization of tammar wallaby IL-1 beta provides fundamental information necessary to progress the study of functional immune responses in this unique group of mammals.
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