Journal
JOURNAL OF VETERINARY MEDICAL SCIENCE
Volume 72, Issue 10, Pages 1301-1306Publisher
JAPAN SOC VET SCI
DOI: 10.1292/jvms.09-0523
Keywords
canine; D-dimer (DD); disseminated intravascular coagulation (DIC); fibrinogen/fibrin degradation products (FDPs)
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We measured the plasma D-dimer (DD) concentration in 205 dogs. Simultaneously, fibrinogen/tibrin degradation products (FDPs) concentration, platelet (PLT) count, prothrombin time (PT), activated partial thromboplastin time (APTT), and plasma concentrations of fibrinogen (Fib) were measured in the same dogs. From these results, we were able to divide the animals into four groups: control (healthy dogs, n=18), pre-disseminated intravascular coagulation (preDIC) (n=20), disseminated intravascular coagulation (DIC) (n=21), and other (n=146). Significant differences in plasma DD concentration were found among the four groups: control, 0.45 +/- 0.46 mu g/ml (reference ranee, 0-1.37); preDIC, 5.0 +/- 4.8 mu g/ml; DIC, 16.3 +/- 12.2 mu g/ml; and other, 1.5 +/- 2.7 mu g/ml. A weak positive correlation (r=0.62) was found between FDPs and DD concentrations in the DIC group. As a DIC diagnostic test, the PLT/APTT/FDPs/DD combination had the highest accuracy of 100%, with a sensitivity of 73% and a specificity of 97%. We propose the use of FDPs and DD concentrations as part of the DIC diagnostic test panel, with DD and FDPs to provide accurate diagnosis.
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