Journal
JOURNAL OF VETERINARY INTERNAL MEDICINE
Volume 28, Issue 2, Pages 576-582Publisher
WILEY
DOI: 10.1111/jvim.12280
Keywords
Objective clinical assessment; Venous oxygen content; Hemoglobin; Anemia
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Background There are no standardized guidelines for determining the likelihood that euvolemic anemic dogs will benefit from transfusion of packed red blood cells (pRBC). Objectives To report clinical and laboratory variables of dogs receiving pRBC transfusion, which could guide transfusion of other anemic dogs. Animals Twenty-four client-owned anemic dogs receiving pRBC transfusion. Methods Prospective study; 30 transfusions assessed. Clinical findings (mucosal color, pulse quality, heart rate, respiratory rate, mentation/exercise tolerance) before and after transfusion were evaluated by the anemic dog clinical assessment score (ADCAS). Hemoglobin concentration, hematocrit, venous oxygen content (CvO(2)), and lactate concentration were measured from blood samples taken before and after transfusion. These results were not used for case management. Results All ADCAS variables decreased significantly with transfusion (P<.001); the total score was >= 5/12 before transfusion, and <= 3/12 in all cases that were deemed to no longer require transfusion. Hematocrit and CvO(2) were <17% and <5mL/dL, respectively, in 83% of cases before transfusion and hemoglobin concentration was <5.8g/dL in 80%. Hemoglobin concentration, hematocrit, and CvO(2) increased significantly with transfusion (P<.001); lactate concentration decreased significantly (P=.006). Conclusions and Clinical Importance Clinical and laboratory variables improved significantly after transfusion of pRBC. By identifying how transfusion affected these variables, it was possible to recognize clinical (ADCAS) and laboratory (hemoglobin, CvO(2), lactate) variables, which could be useful in guiding the decision to transfuse dogs with similar presentations.
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