Journal
JOURNAL OF VETERINARY INTERNAL MEDICINE
Volume 25, Issue 3, Pages 433-439Publisher
WILEY
DOI: 10.1111/j.1939-1676.2011.0694.x
Keywords
Arterial blood gases; Bronchoalveolar lavage; Dog; High-resolution computed tomography; Interstitial lung disease
Categories
Funding
- Orion-Farmos Research Foundation
- Finnish Veterinary Association
- Finnish Veterinary Research Foundation
Ask authors/readers for more resources
Background Idiopathic pulmonary fibrosis (IPF) is a chronic, interstitial lung disease primarily affecting West Highland White Terriers (WHWTs). Objective To describe the clinicopathological and diagnostic imaging features in WHWTs with IPF. Animals Twelve WHWTs with IPF and 14 healthy control WHWTs. Method Prospective study. Clinical signs and findings of physical examination, blood and arterial blood gas analyses, radiography, high-resolution computed tomography (HRCT), bronchoscopy and bronchoalveolar lavage (BAL) of IPF dogs were obtained and compared with controls. Histopathologic changes in IPF dogs were evaluated. Results Mean partial pressure of oxygen was significantly lower in IPF (mean +/- SD, 65.5 +/- 15.4 mmHg) than in controls (99.1 +/- 7.8 mmHg, P <.001). The alveolar-arterial oxygen gradient was significantly higher in IPF (50.1 +/- 17.3 mmHg) than in controls (17.5 +/- 4.9 mmHg, P <.001). In HRCT, ground glass opacity (GGO) was detected in all IPF dogs, traction bronchiectasis in 4, and honeycombing in 1. Bronchoscopic airway changes were noted in all IPF dogs. On BAL fluid (BALF) cytology, the total cell count (TCC) was higher in IPF dogs, and the numbers but not the percentages of macrophages, neutrophils, and mast cells were increased. On histopathology, multifocal or diffuse interstitial fibrosis, type II pneumocyte hyperplasia, prominent intraalveolar macrophages, distortion of alveolar architecture, and emphysematous change were detected. Conclusion and Clinical Importance IPF causes substantial hypoxemia. In HRCT, GGO is a consistent finding. IPF dogs have concurrent airway changes and an increase in BALF TCC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available