Journal
JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES
Volume 18, Issue 4, Pages 432-440Publisher
CEVAP-SAO PAULO STATE UNIV-UNESP
DOI: 10.1590/S1678-91992012000400012
Keywords
Archaeotityus; scorpions; scorpion toxins; Tityus; Tityus clathratus; Tityus serrulatus
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Funding
- Council for Scientific and Humanistic Development, Central University of Venezuela
- Investigation Council of University of Oriente
- Council for Scientific and Humanistic Development, Central University of Venezuela (CDCH-UCV) [PG-09-7767-2009/2]
- Investigation Council of University of Oriente [CI-3-040602-1342/07]
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It has been proposed that the subgenus Archaeotityus comprises the most ancient species group within the medically important scorpion genus Tityus. cDNA encoding sodium-channel active toxins from the type species of this subgenus, Tityus clathratus (central Venezuela), have been isolated and sequenced. Two cDNAs were retrieved that encoded 61 amino acid-long putative neurotoxins named Tcl1 and Tcl2. Sequence identity was highest (87%) when both were compared with beta-toxin Ts1 from the Brazilian scorpion Tityus serrulatus and its homologs from T. bahiensis, T. stigmurus, and T. costatus. A Bayesian analysis indicated statistical support for the grouping of T. clathratus Tcl1 and Tcl2 with Brazilian gamma-like beta-toxins, reinforcing previous phylogenetic studies which suggested an evolutionary relationship between the subgenus Archaeotityus and scorpion species inhabiting southeast South America belonging to the subgenus Tityus.
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