Journal
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 282, Issue 1821, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rspb.2014.3085
Keywords
adaptive immunity; innate immunity; infections
Categories
Funding
- Wellcome Trust New Investigator Award
- Wellcome Trust Strategic Awards
- Wellcome Trust [103830/Z/14/Z] Funding Source: researchfish
- Wellcome Trust [103830/Z/14/Z] Funding Source: Wellcome Trust
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This article reviews the development of the immune response through neonatal, infant and adult life, including pregnancy, ending with the decline in old age. A picture emerges of a child born with an immature, innate and adaptive immune system, which matures and acquires memory as he or she grows. It then goes into decline in old age. These changes are considered alongside the risks of different types of infection, autoimmune disease and malignancy.
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