Journal
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 282, Issue 1805, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rspb.2014.2516
Keywords
dopamine; stress; psychiatric disorders; hippocampus; amygdala
Categories
Funding
- Young Investigator Award from NARSAD-The Brain and Behavior Research Foundation
- United States Public Health Service grant [MH057440, MH101180, DA036328]
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Although, historically, the norepinephrine system has attracted the majority of attention in the study of the stress response, the dopamine system has also been consistently implicated. It has long been established that stress plays a crucial role in the pathogenesis of psychiatric disorders. However, the neurobiological mechanisms that mediate the stress response and its effect in psychiatric diseases are not well understood. The dopamine system can play distinct roles in stress and psychiatric disorders. It is hypothesized that, even though the dopamine (DA) system forms the basis for a number of psychiatric disorders, the pathology is likely to originate in the afferent structures that are inducing dysregulation of the DA system. This review explores the current knowledge of afferent modulation of the stress/DA circuitry, and presents recent data focusing on the effect of stress on the DA system and its relevance to psychiatric disorders.
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