Journal
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
Volume 21, Issue 8, Pages S187-S191Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jvir.2009.12.403
Keywords
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Funding
- NCI NIH HHS [P30 CA008748] Funding Source: Medline
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Cryoablation refers to all methods of destroying tissue by freezing. Cryoablation causes cellular damage, death, and necrosis of tissues by direct mechanisms, which cause cold-induced injury to cells, and indirect mechanisms, which cause changes to the cellular microenvironment and impair tissue viability. Cellular injury, both indirect and direct, can be influenced by four factors: cooling rate, target temperature, time at target temperature, and thawing rate. In this review, the authors describe the mechanisms of cellular injury that occur with cryoablation, the major advantages and disadvantages of cryoablation compared with other thermal ablation techniques, and the current commercially available cryoablation ablation systems.
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