Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 112, Issue 9, Pages 2729-2733Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1418718112
Keywords
G-quadruplex; left-handed helix; nucleic acid; NMR; X-ray crystallography
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Funding
- Nanyang Technological University [MOE2012-T3-1-001, MOE2012-T2- 1-102]
- Centre National de la Recherche Scientifique and Ecole Polytechnique
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Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex. Implications of such a structure in cellular processes, aswell as its therapeutic and diagnostic applications, have been reported. The G-quadruplex structure is highly polymorphic, but so far, only right-handed helical forms have been observed. Here we present the NMR solution and X-ray crystal structures of a left-handed DNA G-quadruplex. The structure displays unprecedented features that can be exploited as unique recognition elements.
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