4.8 Article

AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity

Related references

Note: Only part of the references are listed.
Article Biotechnology & Applied Microbiology

Improving Olefin Tolerance and Production in E. coli Using Native and Evolved AcrB

Florence Mingardon et al.

BIOTECHNOLOGY AND BIOENGINEERING (2015)

Review Microbiology

Molecular mechanisms of antibiotic resistance

Jessica M. A. Blair et al.

NATURE REVIEWS MICROBIOLOGY (2015)

Review Microbiology

Multidrug efflux pumps in Gram-negative bacteria and their role in antibiotic resistance

Jessica M. A. Blair et al.

FUTURE MICROBIOLOGY (2014)

Review Microbiology

Structure and Operation of Bacterial Tripartite Pumps

Philip Hinchliffe et al.

ANNUAL REVIEW OF MICROBIOLOGY, VOL 67 (2013)

Article Biochemistry & Molecular Biology

Some Ligands Enhance the Efflux of Other Ligands by the Escherichia coli Multidrug Pump AcrB

Alfred D. Kinana et al.

BIOCHEMISTRY (2013)

Article Biotechnology & Applied Microbiology

Directed evolution of an E. coli inner membrane transporter for improved efflux of biofuel molecules

Jee Loon Foo et al.

BIOTECHNOLOGY FOR BIOFUELS (2013)

Review Chemistry, Medicinal

RND Efflux Pumps: Structural Information Translated into Function and Inhibition Mechanisms

Paolo Ruggerone et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2013)

Article Infectious Diseases

Genetic inactivation of acrAB or inhibition of efflux induces expression of ramA

A. J. Lawler et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2013)

Article Chemistry, Multidisciplinary

Drug Uptake Pathways of Multidrug Transporter AcrB Studied by Molecular Simulations and Site-Directed Mutagenesis Experiments

Xin-Qiu Yao et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

Article Multidisciplinary Sciences

Structural basis for the inhibition of bacterial multidrug exporters

Ryosuke Nakashima et al.

NATURE (2013)

Article Biochemical Research Methods

Fast gapped-read alignment with Bowtie 2

Ben Langmead et al.

NATURE METHODS (2012)

Article Multidisciplinary Sciences

Exploring Binding Properties of Agonists Interacting with a δ-Opioid Receptor

Francesca Collu et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations

Attilio V. Vargiu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

Thomas Eicher et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Chemistry, Multidisciplinary

Effect of the F610A Mutation on Substrate Extrusion in the AcrB Transporter: Explanation and Rationale by Molecular Dynamics Simulations

Attilio V. Vargiu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Article Multidisciplinary Sciences

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

Ryosuke Nakashima et al.

NATURE (2011)

Article Biotechnology & Applied Microbiology

Evolution combined with genomic study elucidates genetic bases of isobutanol tolerance in Escherichia coli

Jeremy J. Minty et al.

MICROBIAL CELL FACTORIES (2011)

Article Biochemical Research Methods

BEDTools: a flexible suite of utilities for comparing genomic features

Aaron R. Quinlan et al.

BIOINFORMATICS (2010)

Article Biochemical Research Methods

The Sequence Alignment/Map format and SAMtools

Heng Li et al.

BIOINFORMATICS (2009)

Article Biochemical Research Methods

Identification of host-induced pathogen genes by differential fluorescence induction reporter systems

Dirk Bumann et al.

NATURE PROTOCOLS (2007)

Article Biochemistry & Molecular Biology

Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors

Gaby Sennhauser et al.

PLOS BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Comparison of multiple amber force fields and development of improved protein backbone parameters

Viktor Hornak et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2006)

Review Biochemistry & Molecular Biology

Statistical potential for assessment and prediction of protein structures

Min-Yi Shen et al.

PROTEIN SCIENCE (2006)

Article Multidisciplinary Sciences

Crystal structures of a multidrug transporter reveal a functionally rotating mechanism

Satoshi Murakami et al.

NATURE (2006)

Article Multidisciplinary Sciences

Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism

Markus A. Seeger et al.

SCIENCE (2006)

Article Infectious Diseases

BSAC standardized disc susceptibility testing method (version 5)

J. M. Andrews

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2006)

Review Chemistry, Multidisciplinary

Scalable molecular dynamics with NAMD

JC Phillips et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2005)

Article Microbiology

Salmonella gene rma (ramA) and multiple-drug-resistant Salmonella enterica serovar Typhimurium

T van der Straaten et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2004)

Article Biochemistry & Molecular Biology

Dynamics of hydration in hen egg white lysozyme

F Sterpone et al.

JOURNAL OF MOLECULAR BIOLOGY (2001)

Article Biochemistry & Molecular Biology

T-Coffee: A novel method for fast and accurate multiple sequence alignment

C Notredame et al.

JOURNAL OF MOLECULAR BIOLOGY (2000)